First-pass-effect

First-pass-effect
First-pass-effect [fö̱rßtpá̱ßefäkt; engl. first = erster, engl. pass = Zugang, Durchgang u. engl. effect = Effekt] m; -, -s:
teilweise oder vollständige Verminderung der Bioverfügbarkeit eines peroral verabreichten Arzneimittels durch metabolische Veränderungen

Das Wörterbuch medizinischer Fachausdrücke. 2013.

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